3D Guidance for Freehand Prostate Biopsies

Multi-slice to volume registration for prostate biopsy guidance. Left: An axial slice of the fixed multi-slice. Middle-left: A reslice of the moving volume before rigid registration. Middle-right: A re-slice of the rigid registered volume. Right: B-spline deformable registration following rigid registration.

Abstract

In this paper, we present a registration pipeline to compensate for prostate motion and deformation during targeted freehand prostate biopsies. We perform 2D-3D registration by reconstructing a thin-volume around the real-time 2D ultrasound imaging plane. Constrained Sum of Squared Differences (SSD) and gradient descent optimization are used to rigidly align the moving volume to the fixed thin-volume. Subsequently, B-spline de- formable registration is performed to compensate for remaining non-linear deformations. SSD and zero-bounded Limited memory Broyden Fletcher Goldfarb Shannon (LBFGS) optimizer are used to find the optimum B-spline parameters. Registration results are validated on five prostate biopsy patients. Initial experiments suggest thin- volume-to-volume registration to be more effective than slice-to-volume registration. Also, a minimum consistent 2 mm improvement of Target Registration Error (TRE) is achieved following the deformable registration.

Papers

Motion and deformation compensation for freehand prostate biopsies
Siavash Khallaghi, Saman Nouranian, Samira Sojoudi, Hussam A. Ashab, Lindsay Machan, Silvia Chang, Peter Black, Martin Gleave, Larry Goldenberg, and Purang Abolmaesumi
SPIE Medical Imaging, 2014.
Filter-Based Speckle Tracking for Freehand Prostate Biopsy: Theory, ex vivo and in vivo Results
Narges Afsham, Siavash Khallaghi, Mohammad Najafi, Lindsay Machan, Silvia D. Chang, Larry Goldenberg, Peter Black, Robert Rohling and Purang Abolmaesumi
IPCAI, 2014.


Siavash Khallaghi
Last modified: June 15, 2014